NT-proBNP brain natriuretic peptide, a member of the cardiac natriuretic hormones (CNHs) family is secreted by the hemodynamically stressed heart mainly in response to myocardial stretch induced by volume overload.

BNP is synthesized as a 108 amino acid residue precursor and upon release into circulation cleaved into an N – terminal fragment ( NT-proBNP) and the biologically active hormone, BNP-32. The biological half- life of BNP is 20 minutes in comparison to NT-proBNP, which is 60-120 minutes. The amino acid sequence of BNP-32 is highly conserved across species. The BNP gene is localized on chromosome 1.

NT-proBNP has a high clinical significance for:

- Detection of left ventricular dysfunction  (LVD)
- Differentiation between chronic obstructive pulmonary disease (COPD) and
  chronic heart failure (CHF)
- Risk stratification after acute myocardial infarction ( AMI)
- Therapy monitoring of heart failure patients
 

ASSAY CHARACTERISTICS

- Method: Sandwich ELISA, coated strips
- Sample: EDTA plasma, serum
- Sample volume: 50 µl / test - direct measurement
- Standard range: 0-640 fmol/ml
- Detection limit: 3 fmol/ml
- Incubation: 3hrs/30 min

Download:
Package insert
MSDS
CE-Declaration of Conformity

This kit is CE marked, to check availability in the country please contact:

Mgr. Miriam Kraus
Product Manager
Tel.: +421 2 693 099 05
Mobil: +421 902 926 532
Fax: +421 2 693 099 08
E-mail: miriam.kraus(at)bmgrp.sk

Attractive new prices for 2013! - Contact your local distributor for more information!